Lipase

The History & Background of Lipase

Lipase is the digestive enzyme that is needed to digest fat. It hydrolyzes lipids to form fatty acids and glycerol. Lipase breaks down fat in food so that the intestines can absorb it. It is produced in the mouth, pancreas, and stomach. Most people do not need additional LipaseLipase, but for people with cystic fibrosis, Crohn’s disease, and celiac disease may not get the nutrition they need from food due to lack of LipaseLipase.

A small amount of LipaseLipase made by the cells in your stomach is called gastric LipaseLipase. This enzyme digests butterfat explicitly in food. The pancreas is the primary source of LipaseLipase, which makes pancreatic LipaseLipase that acts in the small intestine. The bile produced in the liver and released to the intestine convert dietary fat into little fatty globules. Pancreatic LipaseLipase or steapsin converts these fat globules into fatty acids and glycerol. Fatty acids and glycerol travel in blood and lymph vessels to reach all parts of the body.

In the year 1856, Claude Bernard first discovered Lipase. Animal pancreatic extracts were used traditionally for commercial applications. However, the exploration of microbial sources of LipaseLipase happened when the industrial potential f lipases enhanced and also when the supply from the animal sources did not meet the demand for lipases.

Use in Supplements

Lipase is commonly used for digestion problems due to pancreatic insufficiency that is associated with cystic fibrosis. There have been a lot of reported uses for LipaseLipase that still need more evidence, which include allergies due to gluten in wheat products, Crohn’s disease, indigestion, heartburn, and other conditions. Lipase supplements help control one’s appetite and support healthy and triglyceride levels.

Not all fats are bad for the body. Dietary fat is not considered as an enemy and should not be avoided. One’s health and athletic performance can be improved when the right amounts of good fats (unsaturated) are consumed. Some saturated fats have beneficial effects on athletes, but still, it should only be taken in the right amounts.

Common Dosing

Lipase dosing can vary depending on the chosen supplement. The standard lipase dosage for adults is 6,000 LU (Lipase Activity Units) or 1-2 capsules 30 minutes before meals on an empty stomach, three times per day.

A dose of 4,500 units per kilogram of LipaseLipase per day is recommended for an adult with pancreatic insufficiency that is associated with cystic fibrosis. It is best to start with a low dose first, then gradually increasing it, taking more than the recommended dose without checking the experts is strongly prohibited. Children under the age of 12 are not allowed to take enzymes unless under a doctor’s supervision.

Products Containing Lipase

Potential Side Effects of Lipase

The possible side effects that may occur when taking this ingredient are diarrhea, abdominal pains/cramps, or nausea. Although no severe allergic reaction was reported about this ingredient, it still necessary to remain cautious and even ask from the experts when a rash, itching/swelling, severe dizziness, trouble breathing occur. People with pancreatitis or any pancreas problems are prohibited from using this ingredient. Pregnant and lactating mothers are also advised to avoid LipaseLipase, for it could harm the fetus.

FAQs

What causes abnormal lipase levels?

Lipase levels may be at abnormally high levels if a patient is experiencing:

•acute pancreatitis, which is a sudden inflammation of the pancreas
•chronic pancreatitis, which is a long-term inflammation of the pancreas
•pancreatic cancer
•severe gastroenteritis, or “stomach flu”
•cholecystitis, which is an inflammation of the gallbladder
•celiac disease, which is an allergy to gluten
•duodenal ulcer
•macrolipasemia

Abnormal levels of lipase may also exist in patients with familial lipoprotein lipase deficiency. Drugs that may affect the levels of lipase in your blood include:

•some birth control pills
•cholinergic drugs, including pilocarpine, neostigmine, and bethanechol
•thiazide diuretics
•loop diuretics
•opiates, including codeine and morphine
•meperidine

What are digestive enzymes? What makes them so important?

Digestive enzyme supplementation is an alternative therapy that helps to correct digestive symptoms when certain foods are consumed. The most common type of digestive enzyme deficiency is known as lactose intolerance. Similarly, the decreased production of other digestive enzymes can cause similar symptoms – although many people do not understand the root of their digestive problems. Digestive enzymes are made naturally in the saliva, stomach, and in the small intestine. Every nutrient that we consume has a corresponding digestive enzyme responsible for breaking it down into the building blocks our body uses as energy. In lactose intolerance, the body has decreased output of the digestive enzyme called lactase. Decreased lactase results in lactose passing through the digestive system in an incompletely digested form, manifesting as uncomfortable symptoms. Although lactose intolerance is the most prevalent enzyme deficiency, there are several others. Perhaps even more concerning, nutrients that pass through the digestive system without being completely digested are not absorbed into the bloodstream. This means that the body is unable to reap the benefits of undigested nutrients.

Is it true that bacteria are suitable for your digestive health?

Some bacteria are very important for your health– these beneficial bacteria are known as probiotics. Two important probiotics are Lactobacillus and Bifidobacterium. The health benefits of both of these probiotic bacteria are well studied and supplements are available which can help increase the presence of these beneficial bacteria in your intestines.

Studies

More studies were conducted on the lipase enzyme. A survey of how LipaseLipase can be a potential biocatalyst was conducted. Bacterial lipases were extensively studied, and their commercialization has improved. The potential of bacterial lipases has increased and is now being employed successfully by various industrial sectors. Lipases are inducible, and their yield has been improved using recombinant DNA technology. Through immobilization and bioimprinting, the efficiency of lipases as biocatalysts has been proven effective. The applications of bacterial lipases in food, textiles, detergents, pharmaceutical, and tannery have been well explored.

Studies on Hepatic Lipase suggest its role in HDL metabolism. Evidence indicates that HDL-cholesterol level is at least partly regulated by hepatic lipase level. Recent studies show that not only does hepatic LipaseLipase hydrolyze triglyceride and phospholipid in HDL, but it also stimulates HDL cholesterol level and its function in reverse cholesterol transport. In-vitro model substrate studies, cell culture studies, transgenic animal studies, and clinical studies are where these conclusions were based. It is still not known whether hepatic lipase action decreases or increases the risk of developing atherosclerosis.

Final Review of Lipase

Most of us do not need this ingredient since our body produces just the right amount of LipaseLipase to break down the fats in food so that our intestines can absorb it. However, for people suffering from cystic fibrosis, Crohn’s disease, and celiac disease, taking this ingredient will be a big help in getting the nutrition they need from food. Our body may have enough Lipase, Lipase, but that doesn’t mean we’re not allowed to take it. If you’re curious as to whether you have too little or too much LipaseLipase, a simple blood test could help.

References :

http://healthyeating.sfgate.com/functions-amylase-protease-lipase-digestive-enzymes-3325.html

http://scialert.net/fulltext/?doi=jm.2011.1.24

http://www.healthline.com/health/amylase-and-lipase-tests#during-pregnancy

http://www.umm.edu/health/medical/altmed/supplement/lipase

http://www.livestrong.com/article/350240-risks-of-lipase-supplements/

http://journals.lww.com/co-lipidology/Abstract/2000/06000/Hepatic_lipase_and_HDL_metabolism.8.aspx