Metizolam

The History & Background of Metizolam

Etizolam (also known as Desmethyletizolam), is a psychoactive drug and a synthetic depressant of the thieno diazepine chemical class. It reportedly produces effects that are similar to those of Etizolam, including anxiety suppression, disinhibition, sedation, muscle rest, and memory suppression. It has a 60% longer half-life and is 50% less potent than Etizolam.

In 1995, a Japanese company patented Metizolam as a medication for treating anxiety. Apart from that, there is no known history of human usage until September 2015 when it was released as a grey area research chemical by online vendors.

Etizolam is an analog of benzodiazepine family and is commonly marketed under the names Depas, Etizolam, and Etilaam. Although not much is known about this research chemical, various researches suggest that it possesses hypnotic, skeletal muscle relaxant, sedative, anxiolytic, and anticonvulsant properties.

Use in Supplements

Etizolam is readily available for purchase from the internet in the form of tablets, solutions, and powder. It has excellent potential for abusive use over prescribed benzodiazepines since it can be easily purchased from the internet at lower prices. As of now, scientific literature lacks essential details about Metizolam such as its detailed analysis, and its distribution and metabolism in the body. Although pharmaceutical companies have developed this compound, it does not have any legal status as of now, except in the UK, Sweden, and Canada, where the production/supply of this substance is prohibited.

A Japanese corporation first marketed Etizolam as an anti-anxiety medicinal drug, but little is known about this research chemical. However, a few clinical reviews advocate that Metizolam can act as depressant, sedative, and muscle relaxant.

Metizolam consists of a Thiophene ring fused to a Diazepine ring. Although it structurally differs from its discern compound etizolam as its Triazole ring does no longer comprise methyl institution, however, each has the same fundamental shape, which means Metizolam has the same electricity of affecting cognitive performance in addition to assisting insomnia patients. To decide the exact answer, scientists and researchers must experiment on Metizolam for its role in sleep deprivation prevention. Research labs should buy high prison powders online at studies chemical dealer internet sites to get their excessive first-class studies chemical substances – Metizolam and Etizolam. This may help them to understand the effect of both compounds on people living with insomnia as well as determine the efficacy.

Common Dosing

A proper standard of dosing has not been established yet for this substance since it has not been studied formally and has a minimal history of human usage. However, it is highly recommended to practice caution while administering this substance due to its high potential for abusive use and potential side effects.

Metizolam is a GABAergic (gamma-aminobutyric acid) drug and can tend to be lethal if taken in large quantities with other depressants such as barbiturates, thienodiazepines, alcohol, and opiates. The standard dosing for Metizolam is as follows, with after-effects ranging from 10-30 hours.

Threshold: <1mg

Light: 1 – 2mg

Common: 2 – 4mg

Strong: 4 – 6mg

Heavy: 6mg+

Where To Buy Metizolam online

Potential Side Effects of Metizolam

The harm potential due to long-term usage and toxicity dosage levels of Metizolam are not yet clear since the substance has not been adequately studied and analyzed in a scientific context. This is simply because of the lack of a known history of human usage. However, volunteer members of various research and medicinal communities who administered the substance on its own in low doses have reported no adverse effects; though, nothing can be said for sure.

Dosage is the main factor in determining the effects of Metizolam. If administered in large quantities, Metizolam can yield the following physical and cognitive results.

Physical effects

• Respiratory depression
• Dizziness
• Motor control loss
• Sedation
• Muscle relaxation

Cognitive effects

• Emotion suppression: Although Etizolam primarily dulls anxiety, it also suppresses other emotions in a distinct but less intensive manner than that of antipsychotics.
• Delusions of sobriety: In this condition, one is under a false belief that they are perfectly sober. In contrast, there are clear indications of cognitive impairment and an inability to communicate with others. This condition is usually associated with high dosages of Metizolam.
• Disinhibition
• Analysis suppression
• Compulsive redosing
• Amnesia
• Anxiety suppression
• Thought deceleration
• Euphoria
• Dream potentiation

FAQs

So is the consensus that an equipotent dose of metizolam produces effects indistinguishable from Etizolam? Or very similar?

Or are y’all finding it to be different to a noteworthy degree? I liked Etizolam when I had it years ago, but it has been banned in most of the States that are situated within the close-minded confines of the Bible Belt. Probably because some Congressman’s/woman’s douche son got caught with Etizolam on his person while acting like an ass, douche kids who act like asses while using substances they shouldn’t be using are frowned upon and met with consequences in the Southeastern U.S. So too are the rest of us then who are unfortunate enough to be proximal to said douche and his legislature slinging parent. Their bandwagon is riding neighboring buddies, as they nearly tip over from exceeding the worn-out old wagon’s recommended capacity with their piled high load of reactionary laws and ignorant pride.

So I am liking Etizolam. How does Metizolam compare? Even worth it when Etizolam is around?

Metizolam is good if redosing is difficult, like long days out with people who don’t want you using them drugs. Suitable for tapering if you’ve used it for too long.

Has anyone tried Metizolam? Is it similar to Etizolam or just hype?

Much much weaker. Just stick to Etizolam. If you’re in the U.K., there’s still good etizolam sources around, stay away from OBF, and you’re fine.

Studies

Much is unknown about Metizolam due to the lack of proper scientific researches on this substance. All that is known about this substance comes from the minimal studies carried out and from the data collected from volunteers of different medicinal and research communities who used the importance.

A study was conducted to determine accurate means for detecting Metizolam in urine, as well as preliminary data on its metabolism. A 2mg tablet was ordered via the internet and was orally administered to a 54-year-old man. Urine samples were collected over six days in polypropylene tubes. After liquid extraction at 9.5pH, ultra-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-ESI-MS/MS) was utilized to analyze Metizolam in the urine. Metizolam becomes detectable in hydrolyzed urine during the 46-h length, with concentrations continually decrease than 11 ng/mL. Approximately 0.3% of the initial dose was excreted in urines as total unchanged Metizolam throughout the first 24 h. The most relevant capability CYP- and UGT-established metabolites of Metizolam had been investigated in vitro the usage of human liver microsome incubation and, ultimately, liquid chromatography coupled with quadrupole-time of flight mass spectrometry (UHPLC-Q-TOF-MS) analysis.

Final Review of Metizolam

Metizolam is closely related to Etizolam and has similar effects; however, it is half as potent as Etizolam and possesses a 60% longer half-life. Although Metizolam has certain potential benefits such as anxiety suppression and muscle rest, it should be administered with caution and in small doses because of its harm and abuse potential. Etizolam can tend to be life-threatening if administered with other depressants, including alcohol and opiates.

References:

1. Smokeys. “Metizolam for the Treatment of Insomnia like Etizolam.” High-Quality Research Chemicals Delivered Worldwide To Your Door, 31 Aug. 2017, www.smokeyschemsite.com/index.php?route=blog%2Farticle&article_id=66.
2. “Metizolam.” TripSit Factsheets – Metizolam, drugs.tripsit.me/metizolam.
3. “Metizolam.” PsychonautWiki, psychonautwiki.org/wiki/Metizolam.
4. “GABA.” PsychonautWiki, psychonautwiki.org/wiki/GABA.
5. Haefely, W. “Benzodiazepine interactions with GABA receptors.” Neuroscience letters., U.S. National Library of Medicine, 29 June 1984, www.ncbi.nlm.nih.gov/pubmed/6147796.
6. Weber, Karl‐Heinz, et al. “Heteroaromaten mit anellierten Siebenringen, III. Umwandlung von Thienotriazolooxazepinen in Diazepine.” European Journal of Organic Chemistry, WILEY‐VCH Verlag, 25 Jan. 2006, onlinelibrary.wiley.com/doi/10.1002/jlac.197819780806/abstract.