The History & Background of Myo Inositol Trispyrophosphate
Myo Inositol Trispyrophosphate (ITPP) is a drug candidate, an allosteric effector of hemoglobin, and a potential drug for performance enhancement. This synthetic compound is derived from Myo Inositol Hexakisphosphate, normally produced in mammalian cells and having anti-cancer and antioxidant properties. ITPP augments in increasing the supply of oxygen to tissues by enhancing performance of the red blood cells. It’s not capable of doing so on its own, but rather improves the ability of red blood cells to do so. ITPP has the potential to serve as an effective treatment for hypoxia, a condition causing lack of oxygen supply to the tissues.
As of now, this drug is in stage 1 clinical trials under the compound name OXY111A. Various studies have been conducted testing the effects of ITPP on rodents. These studies revealed ITPP’s potential to boost exercise levels by up to 60%, and its possible ability to strengthen and heal damaged hearts by increasing oxygen supply to the cardiac muscles. It has also been tested on mice to study its potential use in treating cancer, and has yielded positive results. The first clinical trials of ITPP for humans were registered in 2014, aiming to study its potential use as an antitumor agent for patients with hepato-pancreato-biliary neoplasms.
Use in Supplements
ITPP is readily available online in the form of oral nutritional supplements, as well as injectable solutions. Various studies have been conducted to study the effects of ITPP and the results show that it has a high potential for therapeutic usage. The primary benefits of ITPP include a decrease in Hypoxia, increase in exercise capacity, and improvement in the effects of cancer.
It is being increasingly used by athletes across the world since it has the potential to boost exercise levels by up to 60%. A remarkable characteristic of ITPP is that it doesn’t need to be taken frequently. A study conducted by the University of Strasbourg concluded that the beneficial effects of a single ITPP dose can last for up to one week. However, the World Doping Agency has banned the use of this substance for athletes in professional sports since it gives them an unfair advantage. A study was conducted by Görgens et al. (2014) to come up with an effective method for detecting traces of ITPP in human urine, since it is highly polar in nature and thus not detectable via reversed-phase liquid chromatography. Apart from athletes, ITPP has been widely used for horses in the horse racing industry, and has been used on greyhounds and camels as well.
During lab studies, a decent measurement for rats is between 0.03mg – 0.06mg per day. Although ITPP is still primarily intended for non-human research, it is widely being used by athletes. There is no known, precise dosage for humans; however, a survey of various bodybuilding and athletic forums revealed that the common dosage being used by a majority of athletes is between 1g – 2g per week.
Where to Buy Myo Inositol Trispyrophosphate Online
|Myo-Inositol Trispyrophosphate (ITPP) – Powder
Contains: 1000 mg
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|The Myo-Inositol Trispyrophosphate is an allosteric effector of hemoglobin. It has a molar mass of 605.984 g/mol and a chemical formula of C6H12O21P6. It must be stored in room temperature and is soluble to water. Its physical form is solid. It has a chemical name of 4,6,11,13,18,20-hexahydroxy-3,5,7,10,12,14,17,19,21-nonaoxa-4λ⁵,6λ⁵,11λ⁵,13λ⁵,18λ⁵,20λ⁵-hexaphosphatetracyclo[188.8.131.52²,⁸.0⁹,¹⁵]henicosane-4,6,11,13,18,20-hexone.
Potential Side Effects of Myo Inositol Trispyrophosphate
The potential side effects of using Myo Inositol Trispyrophosphate (ITPP) are not yet clear. Athletes have been reporting on bodybuilding forms that despite raising the oxygen level and enhancing workout capacity, this drug does not raise the blood pressure. So far, no side effects of ITPP have been reported except dried skin. Various athletes reported that after using the drug, they didn’t get exhausted for a prolonged period of time and their workout capacity increased by 60%.
WHAT IS ITPP POWDER (MYO-INOSITOL TRISPYROPHOSPHATE)?
Inositol is usually refers to as myo-inositol, a small molecular structure like glucose. Inositol is commonly used as dietary supplements. They are Pseudovitamin compounds which are available in foods but highly available in foods like grains and fruits which have vitamin c with sour taste.
Myo-inositol trispyrophosphate ITT, a noval member permeate allosteric effector of Hb, enhances the regular oxygen release capacity of red blood cells.
HOW TO TAKE ITPP POWDER?
This is useful but to be taken only in sufficient level.
No Over dosage is encourage. This should be taken only by the prescription given by cardiologist.
Times when it should be taken should also be considered properly. Keeping in mind how effective result it gives when taken in which time.
Time gap between taking this doses should also be noted carefully.
Is ITPP The Super Trainer's Drug Of Choice Today?
Andrew Cohen a columnist for Harnesslink has left best for last. His last regular column is all about a fairly new drug that is not being tested for by any jurisdiction in North America called ITPP, which is short for Myo-inositol-trispyrophosphate (NormOxys).
According to Cohen, the drug, developed in France in 2005, “makes the hemoglobin in blood release more of its oxygen, enhancing physical performance in a swift and powerful way.”
This probably explains why certain trainers have unusually high win percentages. The horses that race for super trainers run out of their skin often, putting up very fast times in relation to their class. Another thing that I've observed is the ability for super trainer's horses to rebreak in the stretch, even on the poly track where the average horse has only one real run.
ITPP is affirmed for non human research. Besides, it's prohibited in sports since it gives competitors an unreasonable preferred standpoint. Yet, that hasn't prevented numerous jocks and competitors from attempting ITPP to get an execution help. A few cyclists and other perseverance competitors have utilized this medication as a contrasting option to Erythropoietin (EPO). Numerous famous lifting weights gatherings additionally contain strings where blurbs examine their utilization of ITPP and its advantages.
One thing that competitors adore about this medication is that it doesn't should be taken each day. As the University of Strasbourg contemplate appeared, a solitary measurement of ITPP can give execution improving advantages to very nearly seven days. In spite of manufactured blood substitutes, ITPP upgrades local blood's capacity to supply tissues with oxygen. Also, the medication is very like myo-inositol, a normally happening substance in the body.
Final Review of Myo Inositol Trispyrophosphate
Myo-inositol demonstrates the most guarantee as a dietary supplement for advancing female fruitfulness, reestablishing insulin affectability in occurrences of protection (sort II diabetes and polycystic ovarian disorder being the most all around examined), and for lessening uneasiness also. Because of the blended advantages to insulin protection and fruitfulness, myo-inositol is viewed as a decent treatment for PCOS in ladies.
It additionally holds some guarantee as a stimulant (despite the fact that not as great as its anxiolytic and hostile to freeze impacts) and against some different conditions related with tension, for example, freeze issue and pigging out. It is moderately insufficient for schizophrenia and a mental imbalance, and has bombed in treating PTSD notwithstanding its hostile to freeze impacts.
“Doping Control: Myo-Inositol Trispyrophosphate (ITPP).” Accelerating Proteomics, 30 Jan. 2015, www.thermofisher.com/blog/proteomics/doping-control-myo-inositol-trispyrophosphate-itpp/
Görgens, C, et al. “Screening and Confirmation of Myo-Inositol Trispyrophosphate (ITPP) in Human Urine by Hydrophilic Interaction Liquid Chromatography High Resolution / High Accuracy Mass Spectrometry for Doping Control Purposes.” Drug Testing and Analysis., U.S. National Library of Medicine, www.ncbi.nlm.nih.gov/pubmed/25070041
Duarte, C D, et al. “Myo-Inositol Trispyrophosphate: a Novel Allosteric Effector of Hemoglobin with High Permeation Selectivity across the Red Blood Cell Plasma Membrane.” Chembiochem : a European Journal of Chemical Biology., U.S. National Library of Medicine, 10 Dec. 2010, www.ncbi.nlm.nih.gov/pubmed/21086482
Derbal-Wolfrom, L, et al. “Increasing the Oxygen Load by Treatment with Myo-Inositol Trispyrophosphate Reduces Growth of Colon Cancer and Modulates the Intestine Homeobox Gene Cdx2.” Oncogene., U.S. National Library of Medicine, 5 Sept. 2013, www.ncbi.nlm.nih.gov/pubmed/23045284
Biolo, Andreia, et al. “Enhanced Exercise Capacity in Mice with Severe Heart Failure Treated with an Allosteric Effector of Hemoglobin, Myo-Inositol Trispyrophosphate.” Proceedings of the National Academy of Sciences, National Academy of Sciences, 10 Feb. 2009, www.pnas.org/content/106/6/1926
Limani, P, et al. “Development of OXY111A, a Novel Hypoxia-Modifier as a Potential Antitumor Agent in Patients with Hepato-Pancreato-Biliary Neoplasms – Protocol of a First Ib/IIa Clinical Trial.” BMC Cancer., U.S. National Library of Medicine, 19 Oct. 2016, www.ncbi.nlm.nih.gov/pubmed/27756258.
“Myo-Inositol Trispyrophosphate (Itpp).” AnabolicMindscom Forum RSS, anabolicminds.com/forum/supplements/262192-myo-inositol-trispyrophosphate.html