The History & Background of R-ALA

Type: General Health

Potency: 8/10

R-ALA or R-Alpha Lipoic Acid is found in the varying concentrations in our muscle tissues and organs. R-ALA is a fat and water soluble antioxidant which is responsible for turning glucose in our blood into energy for our cells. It deactivates free radicals circulating throughout the human body which also includes the heavy metals that are a key contributor in developing neurodegenerative diseases. Its health benefits are almost limitless; a few of these are glucose disposal, strong anti-oxidant properties, and anti-aging

R-ALA is endogenous to our cells however its supply decreases as we age. Dietary supplementation is important in order to maximize its effect on our health.

Biochemist Lester Reed Ph.D. first isolated Alpha lipoic acid in 1951. From a sample of liver that weighed 250 pounds, Dr. Reed purified a very small amount of alpha lipoic acid crystals.

Use in Supplements

R-ALA is the purest form available for Alpha-Lipoic Acid. It produces countless health benefits that include glucose disposal, strong anti-oxidant properties, and even for anti-aging. It is a potent insulin-mimicking agent that speeds up the removal of glucose from blood that is usually the profound benefits seen by diabetics.

R-ALA is now a rising ingredient when it comes to fat loss and is now used for fat loss supplements. It also helps break down sugar for the production of ATP making R-ALA also crucial for energy-production. This process ensures that ingested carbohydrates will not be stored as fat but will be used as a fuel instead. It has been reported by many that R-ALA usage can cause higher energy levels for sustained periods of time. To sum up all of its functions in the body, R-ALA supports memory function, fat loss and promote a healthy immune system.

Common Dosing

Doses of 50 to 100 mg of R-ALA per day as a nutritional supplement are recommended. If it is used as a therapeutic agent, higher doses may be possible. A dosage of 600 mg is prescribed in prevention of the damaging effects of hyperglycemia in diabetes in Germany. Larger doses like 1200 mg are used to treat aminita mushroom poisoning. These dosages refer to alpha lipoic acid that contains equal amounts of the R and S version of the molecule, but if R version is the only one used, only half of the dose is required.

Products Containing R-ALA

#3: Doctor’s Best Stabilized R-Lipoic Acid with BioEnhanced Na-RALA
Price: $12.61
Contains: 100 mg of 60
AVG Review: 4.2 stars on Amazon
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The Doctor’s Best Stabilized R-Lipoic Acid has BioEnhanced Na-RALA, the sodium salt of R-Lipoic acid (RLA). Unlike pure RLA, BioEnhanced Na-RALA is a stabilized form of RLA that will not degrade at high temperatures, more bioavailable than regular RLA and has no solvent residues. It plays an important role in glucose metabolism and energy production.
#2: Dr. Danielle Alpha Lipoic Acid
Price: $29.95
Contains: 120 capsules
AVG Review: 4.6 stars on Amazon
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The Alpha Lipoc Acid (ALA) has been used by many people for chronic ailments. Most ALA supplements on the market only contain ALA, not R-ALA but the Dr. Danielle's product contains Alpha R Lipoic Acid (ARLA), which is a natural form of ALA, as well as a healthy dose of S-Alpha Lipoic Acid as well. That makes it more valuable than ALA's in the market.
Price: $42.99
Contains: 120 capsules
AVG Review: NONE
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A proper glucose disposal or optimization is one of the major factors to weight loss and athletic performance. The 1st Phorm’s GDA has been formulated with full efficacious doses of the most potent ingredients available to help unlock your body’s ability to properly deal with high glucose levels.

Potential Side Effects of R-ALA

Proper glucose disposal or optimization is one of the major keys to fat loss and athletic performance.  1st Phorm’s GDA has been formulated with full efficacious doses of the most potent ingredients available to help unlock your body’s ability to properly deal with elevated glucose levels.


What is the difference between R-lipoic acid and Alpha Lipoic acid?

Alpha-lipoic acid consists of a 50/50 mixture of the R- (natural) and S- (unnatural) forms (enantiomers). It is the most widely available commercial form of lipoic acid. R-Lipoic Acid is the form of lipoic acid that occurs naturally in plants, animals and the body and is responsible for the specific beneficial effects of alpha lipoic acid.

How much R- lipoic acid does an adult need?

Currently there are no established daily doses for supplementation. However, GeroNova scientists and medical advisors currently believe the optimal dosing strategy is 100-600 mg/day.

How soon will I see results from supplementing with R-Lipoic Acid?

It will vary depending on your current nutritional state, dosage, and current health. We often hear that our customers “feel better” and experience “clearer thinking” and “enhanced well being” within 2 weeks. For optimal results, we recommend you take our R-Lipoic Acid daily for at least two months to evaluate their benefits.


An animal study using rats showed that administration of alpha lipoic acid in extremely high doses (20 mg/kg) in the presence of a thiamine deficiency is proved to be fatal. A regimen containing alpha lipoic acid can only be beneficial when a B-complex supplement is included with it.

Studies using rats and mice have shown that R-ALA provided protection against the negative effects of arsenic, cadmium, and mercury and may also bind to other metals including iron, copper, and zinc. The chelating action of R-ALA is considered to be relatively weaker compared to other chelating agents. Oxidative damage is associated with some of the harmful effects of heavy metal poisoning. Harmful effects of heavy metals are reduced by lipoic acid’s antioxidant properties.

In liver cells, alpha-lipoic acid has been found to increase oxygen consumption to 189% of baseline when given to old rats at 0.5% of the diet while it nonsignificantly increase oxygen consumption to 104% of baseline in younger rats. Initially the older rats had 59% of the level of oxidation relative to younger rats, and no significant differences were found after supplementation. This normalization of mitochondrial oxygen capacity has been recorded in neural tissue, where increased oxygen consumption with increased anti-oxidative potential improved the neural consequences of aging (such as memory loss) in old rats fed 0.5%/1.5% ALA/ALCAR (a form of L-Carnitine).

Final Review of R-ALA

R-ALA is best described as an ingredient used as a life extension nutrient. It acts in many helpful ways as an anti-oxidant, anti-glycation, blood sugar normalize, activator of mitochondria and enhancement of glutathione. Although R-ALA is natural in the human body, dietary supplementation is still recommended for R-ALA decreases as we age. With its many benefits in the human body including fat loss, it would be a waste to not take this ingredient.

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