If you’re anything like most bodybuilders, you pretty much already know that Letrozole and Clomid are two of the biggest stars when it comes to getting a proper post cycle therapy going. But the thing is here’s the million dollar question: which of the two should you really get your hands on?
Many bodybuilders worldwide are still stumped up until now, too. Let’s give each of these PCT superstars a closer look shortly so you can make an informed decision the next time you’re zeroing in on the stuff to include in your arsenal after completing an anabolic cycle.
In the Red Corner…Letrozole!
At its simplest, Letrozole is a type II aromatase inhibitor (AI) that was initially formulated to treat and curb the relapse of breast cancer in post-menopausal women. Having the brand name Femara, it’s also capable of improving female fertility. It was given the green light by the FDA for distribution and marketing in the United States in 1997.
Interestingly, the American Society of Reproductive Medicine highlighted in a study that Letrozole is very much safe to use even by pregnant women based on the data they’ve gathered.
It’s deemed legal the world over except in India due to the suspicion that it could trigger severe genetic abnormalities among babies born to infertile women. Although the ban was sanctioned in 2011, there are already recommendations to India’s Union Health Ministry to lift it due to the lack of proof of its negative effects.
As an aromatase inhibitor, Letrozole’s counterparts include Aromasin or Exemestane, Teslac or Testolactone, as well as Arimidex or Anastrozole.
How Letrozole Works
Letrozole is basically an aromatase inhibitor or AI, which means that it prevents the aromatase enzyme from converting androgens or male hormones like testosterone and androstenedione into estrogen. This doesn’t just keep the existing testosterone levels of the body intact, but also helps raise the amount of “free” testosterone while at it.
The half-life of Letrozole is approximated at 2 days after administration. However, the blood plasma levels of the users should also be taken into account. Individuals whose blood plasma levels are slower in terms of reaching their peak levels tend to have Letrozole in their system for up to 4 days.
Letrozole Side Effects
Although Letrozole is considered as a safe drug to use, it still has a few side effects that you should keep an eye on when you’re looking to use it for your PCT needs. Besides mild swelling of the extremities, shortness of breath, bouts of lethargy, seasoned bodybuilders also emphasize that the use of Letrozole can set off sudden episodes of chills and flu-like symptoms, as well as fleeting chest pains.
In the Blue Corner…Clomid!
Known by its generic names Clomiphene Citrate and Serophene in the pharmaceutical world, Clomid is a selective estrogen receptor modulator or SERM. As a nonsteroidal, ovulatory stimulant, it was originally put together to treat female infertility by helping stimulate a woman’s body to develop and release an egg, especially among those with polycystic ovaries.
Moreover, Clomid is also prescribed to promote the development of extra ovarian follicles in women whose ovulation cycles are normal, but need a bit of help with the release of healthy egg cells.
Aside from Serophene, other names for Clomid include Clostillbegyt, Clofert, Clomed, Ovinum, Terpafen, Liquid Clomid and Serpafar.
How Clomid Works
Clomid is a selective estrogen receptor modulator or SERM and does its thing by occupying the designated spots reserved for estrogen receptors in the cells. However, it pulls the whole thing off so discreetly that the receptors don’t get activated. They just “think” that the potential estrogen hormones they’re supposed to carry are already in them, so they just go on their merry way, which prevents the production of estrogen.
See, the hypothalamus, the pituitary gland as well as the testes, which are also collectively called as the hypothalamic-pituitary-testicular axis or the HPTA, for short, tend to become very sluggish when it comes to replenishing testosterone levels when you get off an anabolic cycle.
Since the estrogen receptors don’t signal the brain that there is an irregularity in terms of the levels of estrogen produced, this doesn’t just give the body time to bring back its production of testosterone to normal, but also stimulates the HPTA to pump it up.
The half-life of Clomid is about 5 to 7 days. However, experts recommend that you can round the whole thing up to 6 days so you will have an easier reference point to use as a guide.
Clomid Side Effects
According to seasoned anabolic steroid users, the usual side effects to expect when you use Clomid for PCT include blurred vision and similar visual disturbances, stomach cramps, headaches, nausea, and vomiting. There have also been reports of tenderness around the male breast area when taking this SERM.
The Final Decision
Now that we’ve covered all the important details that you need to know about Letrozole and Clomid in terms of their post cycle therapy efficacy, it’s all up to you which of the two suits your PCT needs best. But it’s still very important to take note that getting only the best and most legit products should be the top priority in your checklist!