Advantra Z Extract

The History & Background of Advantra Z Extract

Advantra Z is a stimulant derived from the bitter orange plant. It has synephrine as its primary active compound found in the fruit of the citrus Aurantium plant. Synephrine is also known as bitter orange. Bitter orange is a plant that can be taken by mouth and applied to the skin. The peel, flower, leaf, fruit, and juice are used to make supplements and medicines, while the peel is used to make oil for topical use. Synephrine is chemically very similar to the ephedrine and pseudo-ephedrine found in many OTC cold/allergy medications and several weight loss and energy supplements.

It was known as the “next-generation ingredient” when it was introduced in 1996 by Nutritech. It’s sold through supplement stores and at local retailers. It contains indirect-acting adrenergic amines (B-sympathicomimetics) that facilitate the utilization of energy substrates, stimulate metabolic processes, favor uptake of amino acids into muscle, increase lipolysis (the breakdown of fat) and can exert mild hunger-suppressant effects. This product appears as a light brown to brown powder and is used as a weight-loss and energy supplement.

Use in Supplements

Advantra Z promotes lipolysis, the breakdown of fat, thermogenesis, and the production of body heat in muscle and fat. By promoting lipolysis and thermogenesis, Advantra Z supports the body’s fat loss. The effectiveness of Advantra Z comes from its ability to support the activity of beta-3 adrenergic receptor types, one of four receptors in every cell that support and determine the body’s response to adrenergic amines such as adrenalin and noradrenalin. It binds to beta-3 receptors, which signal the fat cells to degrade stored fat. The adrenergic amines in Advantra Z also support the resting metabolic rate without affecting sensitive alpha-1, alpha-2, beta-1, and beta-2 receptors that could initiate changes in blood pressure and cardiac function.

There are hundreds of supplement lines that sell this brand-name synephrine or citrus Aurantium. The ingredients vary by brand but may include p-synephrine, n-methyltyramine, hordenine, octopamine, and tyramine. You can find it listed as an ingredient in over-the-counter dietary supplements, and it’s sold through supplement stores and at local retailers.

Advantra Z, when used in tandem with high protein intake and a moderate weight-training program, promotes the availability of amino acids to the body to incorporate into protein and build lean muscle mass. When combined with exercise, Advantra Z can also help the body burn fat, build lean muscle mass, and increase physical performance. Not only does it provide additional energy, but it can also help the body use more efficiently the energy stored in fat.

Common Dosing

The standard dosage for Advantra Z extract for 18 years and older is up to 80 milligrams daily by mouth alone or in combination with other ingredients, including caffeine. For an adjunct to surgery, one milliliter of bitter orange blossom per kilogram has been taken by mouth two hours before surgery. For fungal infections, a 25% mixture of bitter orange oil three times daily, 20% bitter orange oil in alcohol three times daily, and 100% bitter orange oil once daily have been applied to the skin. However, for 18 years old and younger, there is no proven safe or effective dose for bitter orange in children.

Products Containing Advantra Z Extract

Potential Side Effects of Advantra Z Extract

Some people have complained of nausea, headache, heart palpitations, jitteriness, and high blood pressure after taking it. Still, the supplements they have taken was composed of more substance other than Advantra, so it’s safe to say that Advantra is not the only reason for these side effects. And according to WebMD, when taken with stimulants such as caffeine or caffeine-containing herbs, it increases the risk for high blood pressure, fainting, and other severe side effects.

FAQs

What is Advantra Z?

Most describe Advantra Z as the safe version of ephedra, the 90’s most successful weight loss drug. But the FDA had to ban ephedra due to its sometimes severe side effects. Nutratech Sciences later patented a side effect-free version called Advantra Z. Advantra Z increases your body’s efficiency in breaking down fats and metabolizing them to produce energy. It is clinically proven to increase the body’s metabolic rate and increase energy. Moreover, it features antioxidant, free-radical scavenging, and anti-inflammatory properties that help protect lean muscles from the stress of physical activity. This key ingredient ensures that you will keep losing weight week after week and avoid the common plateaus associated with other products.

If I have high blood pressure, can I take this product?

No. You should not take this product if you have high blood pressure.

Can I take this with other Transitions™ products?

Yes. You can take this with the other Transitions products.

If I am sensitive to caffeine, can I take this?

Yes. You can still take this product if you are sensitive to caffeine. You may not be able to take more than a half serving until your body gets accustomed to the product. You can also take a half serving just once a day if you need to cut back on the caffeine more dramatically.

Studies

There are many studies conducted on Advantra Z extract. A survey by Kendall-Reed was born in a ten-week system that consisted of two products. One product contained 125 mg hydroxycitric acid (Citrimax^TM), 125 mg bitter orange extract (Advantra Z^®), and 50 mg kola nut extract, while the second product contained 344 mg chitosan. Thirty-two overweight subjects were divided into three groups and either given the two products (one capsule of each in conjunction with each meal), a diet and exercise program, or the products in conjunction with the diet and exercise program. At the end of the study, no adverse side effects were observed or reported. The group consuming the product-only lost an average of 4.63 kg, the group on the diet and exercise regime lost 3.45 kg, and the group taking the product plus diet and exercise lost 6.59 kg. In summary, consumption of the products alone was more effective than diet and exercise, while consuming the products in combination with diet and exercise was most effective. This study was not published and subjected to peer review.

Another study by Haller et al. have examined potential cardiovascular changes associated with a single oral dose of a bitter orange extract (Advantra Z^®) (46.9 mg p-synephrine) and a multiple component dietary supplement (Xenedrine EFX®) which contained 5.5 mg p-synephrine, caffeine, and other ingredients. The protocol consisted of a randomized, double-blind, placebo-controlled crossover design involving ten subjects with a one-week washout between treatments. The results showed that the dietary supplement but not the p-synephrine-containing bitter orange extract increased both systolic and diastolic blood pressures at two hours post-treatment, while heart rate increased at six hours by 16.7 beats/min with the complex dietary supplement and 11.4 beats/min with the bitter orange (p-synephrine) extract. The authors concluded that the pressure effects were not likely caused by C. Aurantium alone since no blood pressure effect was observed with an 8-fold higher dose of p-synephrine. The authors also concluded that the increase in blood pressure might be attributable to caffeine and other stimulants in the dietary supplement.

In a similar study by Gougeon et al., it was investigated the thermic effect of food in conjunction with the phenylethylamine protoalkaloids extracted from C. Aurantium in 30 healthy but mostly overweight (average BMI≈27) male and female subjects. No other ingredients were present in the product. The thermic effect of food on a 1.7 MJ, 30-gram protein meal was determined intermittently for 300 min by indirect calorimetry. Five capsules of the C. Aurantium extract provided 26 mg p-synephrine and 4 mg or less each of the other phenethylamines (Advantra Z^®). The thermic effect of food was determined on an initial 30 subjects. A subset of 11 men and 11 women were additionally studied after ingestion of the bitter orange extract in conjunction with the protein meal. In comparison, another subset of 12 women and eight men was analyzed a third time following the ingestion of the C. Aurantium-containing capsules alone.

Final Review of Advantra Z Extract

As a final review, Advantra Z is a weight loss ingredient employed by many different supplements as a metabolism booster used to burn fat and increase the amount of energy your body produces. Many studies concluded that benefits this ingredient could do, so I would recommend using Advantra Z extract to people who want to lose weight. You can use the recommended products in this article.

References:

http://www.mdriveformen.com/documents/advantra-z-mechanism-of-action.pdf

https://www.dietspotlight.com/advantra-z-review/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444973/