Dimethylethanolamine (DMAE)

The History & Background of Dimethylethanolamine

Type: Stimulant

Potency: 8/10

Dimethylethanolamine (DMEA) or also known as Dimethylaminoethanol (DMAE) is an organic, amino acid compound that is naturally produced in the brain but in small amounts. It can also be found in fishes, such as anchovies, sardines, pilchards and etc. Dimethylethanolamine is an antioxidant, a precursor of Acetylcholine which is a neurotransmitter responsible for the feeling of relaxation.

Dimethylethanolamine can also be a slimming agent. In a study conducted in the 1950’s and 60’s psychiatrists were positive that schizophrenia could be treated by increasing the amount of acetylcholine in the brain. According to the study, the patients lost more than 2 kg of their weight after taking 250 mg of DMEA daily for 4 weeks.

Medicine manufacturers were interested in selling the product for treating ADHD when the studies in the 1970’s showed that it helped alleviate ADHD symptoms but further tests were too expensive so the compound was then packaged as a nutritional ADHD supplement.

Use in Supplements

DMAE is known as a mind-health compound. It won’t make someone smarter but it has benefits against impulsive and disruptive behaviors. It is sometimes referred as cholinergic as it increases levels of acetylcholine (also essential for learning and memory) which explains why it could also be used in treating memory lapses and Alzheimer’s disease.

Aside from mental health, DMAE also supports physical health. DMAE lightens age spots caused by lipofuscin accumulation in deposits within the body. It also improves physical performance. DMAE increases the production of acetylcholine that results to higher energy levels. It also acts as an antioxidant to combat free radicals thus reducing DNA damage.

Common Dosing

The common dosage for Dimethylethanolamine is 100 – 300 milligrams daily but it still varies from person to person.  DMAE is best taken with meals. It is mostly found in powder form, a pill, bulk powder or powder supplements and can also found in topical face and body creams. DMAE is a powerful stimulant and can have some side effects if too much is consumed, which can include insomnia, muscle tension, and headaches.

Products Containing Dimethylethanolamine

#3: NOW DMAE
Price: $7.44
Contains: 250 mg of 100 capsules
AVG Review: 4.2 stars on Amazon
Read More [...]
DMAE may serve an anti-aging function by increasing the body's capacity to produce acetylcholine and has been used most predominantly to improve memory and focus while stimulating neural activityAs a dietary supplement, take 1 Vcaps 1 to 3 times daily, preferably between meals.
#2: Psychosis X
Price: $42.05
Contains: 30 servings
AVG Review: 5 stars on Powersupps UK
Read More [...]
Meet Psychosis X! This effervescent delight boasts high quality DMAE and medical grade niacin; stronger than that stuff your buddy told you to take! And it does not stop there; we packed Psychosis X in easy to grab individual serving packs.
#1: ROYAL 21 QUEEN SYSTEM
Price: $119.99
Contains: 40 Servings Per Container
AVG Review: NONE
Read More [...]
Reaching your weight loss goals doesn’t have to be a monumental task. Royal XXI will arm you with the right tools so you can rule your results. There is no such thing as a magic pill…however, Royal XXI was designed to provide the female body with ingredients to stack the deck in your favor and help you most efficiently and effectively generate the weight loss you are trying to achieve.

Potential Side Effects of Dimethylethanolamine

Although DMAE is usually safe for most people to take orally or topically (as it can also be applied to skin), there are still potential side effects which are constipation, itching, drowsiness, insomnia, excitation, vivid dreams, confusion, depression, increased blood pressure, and unwanted movements of the face and the mouth. DMAE can also potentially increase or worsen schizophrenia symptoms.

There are also people who are best to just avoid DMAE, people with clonic-tonic seizures and pregnant and lactating mothers. Although there aren’t enough reliable sources whether DMAE is safe for pregnant/lactating mothers, it is recommended to just avoid it.

FAQs

How do dimethylamylamine (DMAA) and dimethylethanolamine differ (DMAE)?

I understand that dimethlamylamine (commonly referred to as DMAA) is used in many pre-workouts in order to promote focus, increase energy, and has been said to have many similar attributes of amphetamines. Dimethylethanolamine (DMAE) can be taken to improve mood and mental clarity. I am interested in taking DMAE as a supplement; however, because research on DMAE is so scarce, I could not find if it affects the heart like DMAA does–increased heart rate. I do not take any stimulants and want to avoid DMAE if it also works like amphetamines. I am looking for more information on DMAE. Any links to websites with more information would be great.

Is DMAE a good Nootropic?

DMAE is a conditionally good nootropic, based on conditions that we haven’t yet fully realized. Which isn’t the most insightful conclusion to this review, but it’s the best I can give.

Frankly, DMAE is a cheap ingredient, averaging around $8 to $9 dollars per monthly supply. That alone should warrant your consideration, even if you’re only moderately curious on what this nootropic could do for your cognition.

How long does it take for the effects to kick in?

When taking orally most people will begin to feel the stimulant like effects within 30-45 mins.

Studies

In a dietary study, rats were exposed to DMAE at dosages of 0.045 g/kg up to 0.89 g/kg in the diet over 90 days.
Although increases in liver and kidney weights were observed at the highest dose level (0.89 g/kg), there were no changes noted in the liver or kidneys during microscopic examination of these organs.

In a vapor inhalation study, rats were exposed to DMAE vapors of 0, 8, 25 or 75 ppm for 6 hours per day, 5 days per week, for 13 weeks. The rats exposed to 25 and 75 ppm DMAE showed a transient corneal opacity. In addition, rats exposed to 75 ppm over the course of this study showed decreased body weight gain and lesions of the respiratory and olfactory epithelium. These findings are not unexpected, due to the dermal corrosive properties of DMAE.

In this study, female rats were exposed to DMAE vapors of 0, 10.4, 29.8 or 100 ppm for 6 hours per day on gestational days 6 through 15. Maternal toxicity (reduced weight gain and ocular changes) were observed in the 100 ppm group only. There was no consistent pattern of fetal toxicity or developmental effects noted in the offspring.

Final Review of Dimethylethanolamine

Most people who take DMAE do not experience any bad side effects but there are still cases where one could experience side effects from taking it. I suggest that anyone who would take this supplement should avoid taking more than its recommended dosage. DMAE shouldn’t also be used by people with bipolar disorder and those who are epileptics. I would highly recommend it to athletes, body builders, and people looking to improve everyday performance, energy, or cognition.

References:

http://www.progressivehealth.com/adhd-dmae.htm

DMAE as slimming supplement

https://nootriment.com/dimethylaminoethanol/

https://examine.com/supplements/dmae/

https://forum.bodybuilding.com/showthread.php?t=590002

https://forum.bodybuilding.com/showthread.php?t=139514683

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