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The History & Background of L-Isoleucine


L-isoleucine is one of the essential amino acids that the body cannot produce and must be acquired thru diets. It is famous for its ability to increase endurance and repairs and rebuilds muscle cells. This is helpful to bodybuilders for it helps regain and give energy as well as help the body to recover faster after intense training.

It also supports repair muscle tissue through blood clotting and improves your stamina. L-isoleucine is widely used by bodybuilders and athletes. Meat, fish, eggs, nuts, seeds, and pulses are some of the few high protein foods that are a source of isoleucine.

Use in Supplements

People who exercise a lot should supplement themselves with isoleucine. Although there is no sufficient evidence, isoleucine can increase muscle mass and improve athletic performance, preventing amino acid deficiency and reduction of acute diarrhea in children.

It should be taken together with other branches to see more effective results. It plays an integral part in protein synthesis, which I needed by bodybuilders to spare other amino acids from burning.

Common Dosing

Isoleucine is a supplement that is beneficial to those who want to increase their glucose uptake. For effectiveness, 0.3-0.45g/kg in rats and a dosage range of isoleucine per se is 48-72mg/kg for a 150 lb person.

Products Containing L-Isoleucine

Nutricost L-Isoleucine 2000mg Per Serving, 240 Capsules (60 Servings)

Potential Side Effects of L-Isoleucine

There are no reported side effects of the supplement, yet unable to take the optimal dosage that best suits you may result in stomach upset and indigestion.


Q: What is L-isoleucine?

A: Isoleucine is one of the essential amino acids, which means we need to take it in the form of the food we eat each day. Most people generally get enough isoleucine from their diet, but some people can become deficient and may need to supplement their diet.

Q: What are the dangers of taking isoleucine?

A: As isoleucine is an essential amino acid, it does not appear to have many dangerous side effects, but any supplementation should be taken at the lower dosage first and increased as long as you do not experience an adverse reaction, plus, you should always inform your doctor about all supplements you take, so they are aware of this and can advise you according to your particular situation.

Q: What are the essential amino acids?

A: Essential amino acids cannot be produced by the body, requiring you to get them through food and nutritional supplements. Essential amino acids include:

  • L-leucine
  • L-isoleucine
  • L-lysine
  • L-methionine
  • L-phenylalanine
  • L-threonine
  • L-tryptophan
  • L-valine
  • L-arginine
  • L-histidine


A study utilizing 0.3-1.35g/kg of L-Isoleucine discovered pinnacle viability at 0.45g/kg, which hoisted serum fixations to 3mM, and the decrease in serum glucose achieved 20%. In comparison, substantial glucose take-up expanded 71% (73% noted somewhere else with 1.35g/kg). Total body glucose oxidation developed 5.1-6.0% following 30-a hour and a half (more adequacy at 30 minutes).

Another study utilizes 1.35g/g (same adequacy as 0.45g/kg) noticed that the serum focus was 4352+/ – 160μmol/L which was genuinely comparative (somewhat higher) than the serum fixation noted with 0.45g/kg; this proposes the rate furthest reaches of isoleucine happens at either ingestion or conveyance to the blood.

One study utilizes both an amino corrosive blend (98% isoleucine by weight) and insulin noticed that while the corrosive amino blend (2.0334mM) was equivalent to submaximal insulin emission, it was less successful at advancing glucose take-up than maximal insulin discharge; be that as it may, the high isoleucine blend went insulin-instigated glucose take-up at both submaximal 26% and maximal 14% fixations.

Final Review of L-Isoleucine

Isoleucine is stronger than valine but much weaker than leucine. It enables increasing of glucose during intense exercise. Its primary function is to boost energy and helping the body to recover from any physical activity that needed much energy. Patients who suffer from liver or kidney malfunction must first consult a physician before taking isoleucine.






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