The History & Background of Osthole
Osthole – also spelled osthol – is a type of coumarin, a phytochemical with vanilla-like a flavor found in many plants, notably in high concentration in the tonka bean, Woodruff, and bison grass. It has a sweet scent and can occur either free or combined with the sugar glucose. Osthole can be found in an active constituent isolated from the fruit of Cnidium monnieri, a Chinese herbal medicine, which has been used to treat anti-inflammation, anti-osteoporosis, and anti-tumor for many years. It can be found in several other plants. It may increase androgen, gonadotropin, and nitric oxide synthase (NOS) activity.
Recently, researchers from Medical School of Soochow University, China, found that ostiole could inhibit alcohol or high fat-generated fatty liver in mice in 4-week-supplementation, most likely correspond with its anti-oxidation and suppression of TNF-alpha production.
Use in Supplements
Osthole Benefits:
- Osthole benefit for fatty liver
- Osthole improves fat milk-induced fatty liver in rats: modulation of hepatic PPAR-alpha/gamma-mediated lipogenic gene expression.
- Osthole may benefit people at risk of hypertension.
- Osthole causes hypotension in vivo or lowers the blood pressure of animals, and inhibits platelet aggregation and smooth muscle contraction in vitro.
- Researchers noted that the mechanism might work via interfering with the calcium influx and cyclic nucleotide phosphodiesterases.
We still see some wonder in the field about whether Osthole has farther-reaching effects than just erectile dysfunction and potency issues in men. And specifically, it is women who may wonder whether this particular herbal remedy can help them in some ways as well.
After all, low potency, low libido, and excess anxiety are not problems of men alone. Couldn’t this natural herbal remedy help women with low libido or anxiety?
Like many herbal remedies, Cnidium and its main ingredient Osthol has not been scientifically studied to the extent that we can answer those questions. In other words, the honest answer is that we must do not know.
But we have to say that the possibility that Osthole could be helpful to women, and is underused for them, is one that we need to consider.
Other natural herbal remedies that were once pigeon-holed as doing only one thing or working for just one particular population often disproved that notion when others tried them. Many herbals do more than they were initially thought to do or use in ways that they were initially not believed to work. But it takes a small group of people to take the herbal remedy even though they do not have the core issue it is known to fix, or even though they are in a group not known to benefit. And this is something that even we, as big fans of Osthole, hesitate to suggest. Even though there are few side effects of Cnidium, we still feel like people should take it if there is existing evidence that it will specifically help them.
Common Dosing
Since there is no information on Osthole consumption in isolation, the best lead currently is the dose of Cnidium fruits or seeds used in Traditional Medicine, which is 6-15g of either fruit or grain.
The appropriate dose of Cnidium depends on several factors, such as the user’s age, health, and several other conditions. At this time, there is not enough scientific information to determine an appropriate range of doses for cnidium. Keep in mind that natural products are not always necessarily safe, and dosages can be significant. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
Products Containing Osthole
Cnidium Monnieri Extract 50:1-60 500mg VegiCaps – Stearate Free, Bottled in Glass! Free Shipping on Orders Over $49!Potential Side Effects of Osthole
Mental effects
Osthole improves aspects of spatial performance in ovariectomized rats.
Am J Chin Med. 2004.
The present study was designed to investigate the ameliorating effects of Cnidium monnieri and ostiole, a constituent of cnidium, on the spatial performance deficit in scopolamine (SCOP)-treated or ovariectomized rats. Osthole improved the performance deficit in ovariectomized rats. The action mechanism of the effects of osthole on performance deficits was related to the estrogen-like properties and activating the central cholinergic neuronal system.
Osthole side effects may be more prominent because you are getting a more potent dose of the active ingredient in these supplements.
Special Precautions & Warnings:
Pregnancy and breast-feeding: Not enough is known about the use of cnidium during pregnancy and breastfeeding. Stay on the safe side and avoid use.
FAQs
What are the benefits of Osthole?
It is an Anti-inflammatory Action. It may also benefit people suffered from some chronic conditions and risk of hypertension.
How does Osthole work?
Chemicals in cnidium might decrease itching.
What is Osthole used for?
Erectile dysfunction (ED). Difficulty having children (infertility). Bodybuilding. Cancer. Weakened bones (osteoporosis). Infections. Increasing energy. Skin conditions including itchy skin, rashes, eczema, and ringworm, when applied to the skin.
Studies
Osthole is commonly seen as the primary active ingredient due to its being the most prominent coumarin derivative in Cnidium Monnieri and is a coumarin derivative compound.
The product Cnidium Fruit Extract and its constituents Osthole has complete applications and may be used in different fields, including herbal teas, drinks, supplements, and cosmetics, etc., there is some introduction of its brief application guide both traditional and modern.
Osthole: a natural approach to speed up bone fracture healing
Bone fractures are among the most common orthopedic problems that happen to many of us. Although our body will naturally repair a broken bone, the healing process takes weeks, months, or even years, depending on the severity of injury and complications. Even in worse cases, elderly, smoker patients, and patients with metabolic diseases such as osteoporosis or diabetes have much longer healing time and a higher risk of developing nonunion (non-healing of the bone). Fortunately, we can make a significant augmentation during the recovery process by merely working with nature. There are many different herbal remedies for speeding bone healing, including arnica, wild comfrey, boneset, and numerous effective ingredients that were isolated from those herbs. Herbal therapy not only helps fracture repair but also strengthens bones and lessen the chances of bone fragility. Here we introduce another promising herb ingredient that can help to heal broken bones.
Osthole is a naturally derived coumarin, which is the main bioactive compound isolated from medicinal plant Cnidium monnieri (L.) Cusson. This herb is commonly used as one component in herbal formulas for bone strengthening by traditional Chinese medicine practitioners. In this study, we investigated the effect of osthole on bone fracture repair using the femoral open fracture model in mice. A transverse fracture was created in the middle of the femur with a saw. Operated mice were given with 20 mg/kg osthole solution or solvent alone by oral gavage every day since postoperative week 1. The bone healing process of both groups was assessed by commonly used techniques like plain radiography, micro-computed tomography, histology analysis, as well as molecular imaging showing bone regeneration.
Nootropic and Neuroprotective Effect
The benefits of osthole and Fructus Cnidii (FC) extract on the nervous system have been investigated in recent years. Osthole regulates ion channels and G-protein-coupled receptor (GPCR) activities influencing neuronal and neuroendocrine function.
Osteogenic Activity
Bone modeling effect is one of the bioactivities osthole showing the most promising therapeutic potential. Plenty of in vitro studies has been demonstrated that osthole and coumarin extract from FC promoted proliferation and differentiation of osteoblasts and suppress the formation and activity of osteoclasts, hence tipping the balance in favor of bone remodeling and increasing bone density, which makes osthole a potential agent for osteoporosis treatment.
Anticancer Effect
Accumulating experimental evidence has shown that osthole exhibited antiproliferative properties and induced apoptosis in various kinds of tumor cells, including leukemia; prostatic cancer cell; cervical cancer cell Hela; ovarian cancer cell; lung cancer cell; epidermal cancer cell; breast cancer cell; and hepatocellular carcinoma (HCC).
Hepatoprotective Effect and Benefits of Metabolic Diseases
The liver is regarded as one of the vital organs that function as a center for the metabolism of nutrients and excretion of wastes. Osthole exerts protective effects against hepatitis. It suppressed the secretion of hepatitis B virus (HBV) in cell culture and prevented hepatitis in mice induced by concanavalin A or anti-Fas antibody. Osthole also exhibited a therapeutic effect on both hyperlipidemic and alcoholic fatty liver animals.
Vasorelaxant Properties and Cardiovascular Benefits
Osthole exhibits a protective effect on the heart and circulatory system. Abnormal vascular smooth muscle cell proliferation is a significant component of vascular disease, including atherosclerosis, vein graft occlusion, and restenosis after angioplasty. In contrast, osthole treatment selectively inhibits the proliferation of those vascular smooth muscle cells.
Antimicrobial and Antiparasitic Effect
Osthole exerts antifungal properties on the numbers of fungi species. Experimental shreds of evidence showed that osthole inhibited hypha growth of Fusarium graminearum, a parasite found in common weeds and cereal crops, through glucose starvation, and controlled powdery mildew caused by Sphaerotheca fuliginea via inhibiting spore germination and mycelia growth.
Final Review of Osthole
What a naughty ingredient we have here. This Osthole is for men who suffer erectile dysfunction, and this would be men’s effective supplement for better sexual performance. Take note, always check the label and follow guidelines as well. For extra assurance, ask medical experts about it.
References:
Osthole benefit and research, osthol, review of health benefits and side effects
Osthole: a natural approach to speed up bone fracture healing
Osthole