Vitamins & Antioxidants

Protandim Review: All-Natural Antioxidant or All-Hoax?

Today is the start of your healthy living lifestyle. Back it up with Protandim product which is said to allegedly prolong life. Its patent application claimed that it was useful to treat or prevent an astounding 126 diseases and medical conditions, from tinnitus to aging, from hemorrhoids to cancer.

Protandim is said to work by helping the body increase its own natural antioxidant enzymes. Sounds fancy, but does Protandim really work or is it a hoax? These are some of the questions I want to address in this Protandim review.

The good thing about Protandim is that there is actual, published peer-reviewed research studies on this product. By the end of this Protandim review, we truly hope that you’ll have a better idea whether Protandim is right for you.

What is Protandim?

Protandim is “clinically proven to reduce oxidative stress to levels of that of a 20-year-old.” Oxidative stress refers to the stress (cellular damage) caused by free radicals. might sound like a drug but it’s really a dietary supplement that is said to combat free radical damage (oxidative stress) by stimulating the production of the body’s own natural antioxidant enzymes such as catalase, superoxide dismutase (SOD) and glutathione.

So, instead of taking individual antioxidant supplements (like vitamins C, E, etc.) in the hopes that they will battle free radicals and combat aging and disease, Protandim is supposed to ramp up your own naturally occurring free radical defenses.

Protandim is a patented dietary supplement marketed by LifeVantage Corporation (NASDAQ: LFVN; formerly LifeLine Therapeutics, Lifeline Nutraceuticals, and Yaak River Resources, Inc), a Utah – based multi – level marketing company. The manufacturers of Protandim claim the product can indirectly increase antioxidant activity by up-regulating endogenous antioxidant factors such as the enzymes superoxide dismutase (SOD) and catalase, as well as the tripeptide glutathione.

But, just like all dietary supplements, Protandim has not been evaluated by the U.S. Food and Drug Administration (FDA).

Breakdown of Ingredients of Protandim

This is how the ingredient label looks like:

Protandim is manufactured using five natural ingredients. But, when taken individually, these ingredients cannot achieve the same effects of the patented and especially for the formulated Protandim. The ingredients are:

  • Milk Thistle Extract – Used for centuries, milk thistle protects the liver and supports the liver function.
  • Bacopa Extract – Bacopa is a memory booster, aiding in concentration and learning.
  • Ashwagandha Root – This is used for its antioxidant properties. For centuries, it also has been used for increased energy and longevity.
  • Greem Tea Extract – Green tea has antioxidant and weight – loss properties.
  • Turmeric Extract – Has antioxidant properties. In the past, it has been used to treat digestive disorders and regulate bleeding.

Ingredients of the said product yield to excellent results as they can work harmoniously together that lead to the improvement of our body

Protandim Side Effects

There are no expected side effects for the typical Protandim consumer. However, there might be some individuals that may have natural allergic responses to one or more of the ingredients, just as some people are allergic to pollen or penicillin.

These responses generally appear as:

  • Gastrointestinal disturbances
  • Headache
  • Rash on hands of feet

These symptoms typically disappear if Protandim is discontinued. If you have an adverse reaction experience because of this, we highly recommend discontinuing the use of this product.

Protandim Reviews

Protandim is really unique that other supplements because they have a valid proof and basis of the said product. There really is published, peer reviewed research on this supplement. There are also multiple positive feedbacks from the Protandim consumers. See the following:

“I have extremely bad anxiety and a high-stress level and this Protandim have helped both those issues. It has also helped with keeping a clear head and not being so tired and drained all the time. I would highly suggest this product to anyone!” 

“Protandim has helped my blood pressure and blood sugar levels after a month of use. I also have more restful and energizing sleep. I am definitely reordering the product and recommending it to all of my friends.” 

“I have been using Protandim for several years and find it helps with inflammation. Oxygenation of the body helps keep us younger.” 

Protandim has been getting solid five stars from the consumer of the products and it just tells us that it really is a good supplement. Some people would even claim that it is the best product.

Advantages and Disadvantages of Protandim


  • Easy to take at only one caplet a day and have it with food for good absorption
  • 100% natural and is classed as food
  • Affordable @ Retail US $50 for a one-month supply (20% discount if purchaser chooses to be a preferred customer and/or distributor)
  • Scientific Validation and Peer Review studies current and readily available online
  • Sold by network marketing company LifeVantage Inc. This means the product is readily and easily available in the countries LifeVantage has distribution centers and product is delivered to your door.
  • The supplement works as a remedy to most of the lifestyle diseases as well as prevention of early aging due to stress.


  • The company offers a very short money back guarantee of one month and still the conditions for refund may not favor the customers as the products need not be opened for one to be refunded, yet one needs to try out the product so as to know if they really work out for them or not.
  • The product is currently limited to some countries such as US, Canada, Hong Kong, México, Japan and Australia and this may make it hard for those potential l buyers from other countries to make orders.
  • Some people are allergic to some of the supplements’ ingredients’ and thus they may not be able to enjoy the benefits of this supplement and those that may insist on taking the supplement despite being allergic, they may end up experiencing some negative impacts.
  • If one made and order and they need to cancel it or even want to close an account, the process is quite complicated for one need to call LifeVantage office as they are the ones to cancel.
  • Some salespersons may exaggerate the health impacts of the supplement as some claim that it prevents death and old age and this may make the customers buy the product for wrong reasons.

Where to Purchase Protandim

The best place to buy this product is directly from the company or from accredited distributors so you can guarantee that you are getting the real thing.

Final Verdict and Summary

Protandim has gained a lot of reviews over years, and the most outstanding question about the product is whether it actually works or not and whether it is safe or not.

In conclusion, it is clear that different clients have totally different feelings about the Protandim. Those that have used the product and have worked for them cannot think of going for a different supplement at the expense of Protandim yet those that have been failed are just but frustrated. The best thing to do is to consult an expert before using supplements so that they can tell that which works out for you depending on your healthy needs.

Just like in anything, it would always take two results, the ones who liked the product and the ones who don’t.

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Ingredients and its General Clinical Reviews

  • Milk Thistle Extract – A 225mg pack of Protandim supplement consists of 80% Silymarin. Some people even apply this extract so as to ease the skin toxicity caused by radiation. This product is a carrier of antioxidant and anti-inflammatory effects and that could be the reason why it perfectly works in the protection of the liver from toxic chemicals and drugs.
  • Bacopa Extract – This is a plant extract that has been used as a medicine for years in India. Bacopa works by increasing a certain brains chemical that enhances in thinking, learning, and memory and may also protect the brain cells from Alzheimer’s disease attack.
  • Ashwagandha Root Powder – This is yet another Protandim ingredient which also has some independent benefits. The ingredient is used to tone, support and revitalize bodily activities.
  • Green Tea Extract – This happens to be the healthiest ingredient. It is loaded with antioxidants and some other nutrients which are considered to be so healthy in the body.Green tea can also lower the risk of type II diabetes as well as protecting the brain in old age.

Clinical Research

The first human trial was published in the journal Free Radical Biology and Medicine in January of 2006. All the subjects knew the ingredients they were taking and were aware of their supposed potential. It’s no big surprise that the results of that trial were positive.

A 2008 review article noted that while many supplements are claimed to act as antioxidants, changes in the levels of TBARS (Thiobarbituric Acid Reactive Substances) and increases in the levels of antioxidant enzymes in response to a treatment do not provide a reliable indication that the treatment has an antioxidant effect, since the same responses are produced by pro- oxidant compounds that induce oxidative stress. The authors suggested that measurement of isoprostanes might be a better indication of lipid peroxidation and oxidative damage to DNA.

A 2011 blog by Harriet A. Hall in Science-Based Medicine stated, “We simply don’t know enough at this point to recommend Protandim for treatment or prevention of any disease, for anti-aging, for making people feel healthier or more energetic, or for anything else.”

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  • Gastrointestinal disturbances – This is commonly associated with the symptoms of stomach pain, heartburn, diarrhea, constipation, nausea, and vomiting.

Causes: There are multiple reasons that trigger gastrointestinal disturbances.  These contributors are: Nutrient deficiencies, pollution, poor diet, dehydration, stress, poor sleeping habits, and lack of exercise are among the long list of contributors to these staggering statistics.

Causes: Causes of headaches may include fatigue, sleep deprivation, stress, the effects of medications, the effects of recreational drugs, viral infections, loud noises, common colds, head injury, rapid ingestion of a very cold food or beverage, and dental or sinus issues.

  • Rash on hands or feet – This is when the skin is exposed to something irritating. It reacts with a certain allergen that you ingested or came in contact with. It is a noticeable change in the texture or color of your skin. Your skin may become scaly, bumpy, itchy, or otherwise irritated.

Causes: There are numerous causes for rashes such as allergies, medications, cosmetics or can be a certain disease such as chickenpox and measles.


Should I continue to take my other vitamins and antioxidants?

Some Western diets are lacking in certain nutritional elements, so multivitamin supplementation may be beneficial for some people.

Is this product safe to take with prescription medication?

Please consult your physician if you are taking any medication before use.

Can I use this product if I am pregnant or nursing?

No, we do not recommend this product if you are pregnant or nursing.

Can children take this product?

No, we do not recommend this product for children. Our products are made for individuals 18 and older.

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Protandim is best taken with food. The active ingredients in Protandim are fat soluble. Although it is not absolutely necessary, taking Protandim with a meal containing some fat allows the ingredients to be absorbed more efficiently.

  • One caplet per day is the recommended dosage. Most people prefer taking Protandim in the A.M.
  • Two caplets may be recommended for those with high levels of oxidative stress, such as athletes.Those with more serious health conditions and smokers may also wish to try taking 2 or more than two caplets should not be necessary. If taking 2, try taking them at different times of the day.
  • Sensitive individuals and those with a tendency to allergies should test out a half (or even a third) of a cap for several days. Then proceed to a full caplet. Protandim can even be dissolved in a glass of water, sipping a little now and then over the course of a day.
  • Those with medical conditions can also follow a gradual increase and should monitor medication levels closely with their doctor as their biochemistry changes.
  • Take medications separately from Protandim. Those taking Coumadin should check within a couple of days to see if their clotting time has changed and their dosage may need adjustment.

Everyone is different and, therefore, will have a different experience. Individual lifestyle factors, activity level, overall health status, nutritional intake, and constancy will affect the outcome. Some results may be rapid and dramatic, while others are subtle and gradual.


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