3,5 Diiodotyrosine

The History & Background of 3,5 Diiodotyrosine

There are many chemicals and herbs utilized as a part of weight loss supplements. While some of these supplements require a doctor’s prescription, others are accessible over-the-counter, and one of these supplements is Diiodotyrosine. It is a hormone that is delivered during the production of Thyroxine (a thyroid hormone). Diiodotyrosine is an iodine-containing compound. As you might know, iodine can help with thyroid gland function.

Diiodotyrosine (DIT) is a forerunner in the creation of thyroid hormone and results from the iodization of monoiodotyrosine at the other meta-position on the phenyl ring. It is a modulator of the enzyme thyroid peroxidase.

Use in Supplements

3,5-diiodo-L-thyronine (T2), has found its way to be incorporated with various dietary supplements that claim to remove body fats. They are accessible “over the counter,” and if you look over the internet, there are many marketing verbiages that offer products such as fat burner, appetite suppressant, quick fat annihilator, and metabolic accelerator. The T2 content per pill may vary essentially among various supplements (50–300 μg), and sometimes, it is not explicitly expressed. In many cases, T2 is consolidated with different mixes with overlapping or complementary biological effects, making it hard to observe which of the metabolic results the particular impact of the T2 activity.

Common Dosing

The suggested dosage for 3,5 Diiodotyrosine is 400 mcg that is found in a single capsule in supplements. 1 to 2 capsules twice daily, with or without food, or as recommended by your health care practitioner. When increasing dose, do so gradually to a maximum amount of 4 capsules, twice daily. Never exceed eight tablets in 24 hours.

Products Containing 3,5 Diiodotyrosine

Potential Side Effects of 3,5 Diiodotyrosine

The use of diiodotyrosine was observed to have no significant side effects so far. However, very high doses of this will have a harmful effect at the cardiac level and on the HPT axis. Researchers are still studying the side effects of 3, 5 diiodotyrosine if used for a long time.

FAQs

Over-The-Counter Thyroid Hormone?

Recently, Biotest Laboratories has released a very interesting product that they are calling T2 (otherwise known as 3,5-diiodo-l-thyronine or just diiodothyronine). T2 is definitely a legitimate thyroid hormone, structurally very like T3 or T4. However this product is allowed to be sold as an over the counter dietary supplement due to the fact that is present in meat.

How’s The Thyroid Working?

Now that you’ve seen what thyroid hormones can do, let’s talk about thyroid function. Much like any other hormone system there are tight controls regulating thyroid function. So under most normal circumstances, if thyroid concentrations are low in the blood then the thyroid is stimulated to produce more hormone. And if they are high in the blood, the thyroid will be inhibited and less will be produced. Of course there are a few exceptions to these rules. Disease states, prescription medication use, and interestingly, dieting can throw off this equilibrium. While most people don’t have thyroid disorders or use meds that can alter thyroid function, most people do diet at some point in their lives. And during dieting, natural thyroid production is usually suppressed and this can eventually harm fat loss efforts.

What is T2 or Diiodotyrosine?

T2 belongs to the family of iodine-dependent thyroid hormones known as iodothyronines, although it is generally considered less active than T4 and T3, as are rT3, 3’3’T2, and 3’T1. It was previously thought to be a catabolite of T3, but studies have shown that T2 is made by the deiodination of T3 and rT3 (possibly more so from rT3) and mimics the effects of T3 on energy metabolism. So while it does appear to be closely related to T3, it has been demonstrated to be metabolically active, possessing its own mechanisms of actions separate from T3.

Studies

There was a study that the use of T₂ by humans as a metabolism inducer stems from initial findings by Horst et al. and Lanni et al., who observed that T₂ rapidly induced hepatic oxygen consumption and oxidative capacity. In the last two decades, work from Goglia’s group and others expanded on these findings. It confirmed T2’s effects on mitochondrial function, fat mass, lipid metabolism, and its positive influence on insulin resistance, further supporting the case for T₂ use to enhance metabolism.

In another more complete study published in the current issue of Endocrinology, Wenke Jonas and investigators in the laboratories of Joseph Kohrle and Annette Schurmann used a mouse model of obesity to analyze the physiological effects of T₂. In their thoughtfully designed, carefully performed, and thoroughly discussed experiment, the authors treated obese mice for 2 and 4 weeks with two different daily doses of T₂ or with a supraphysiological amount of T₃ and measured several metabolic and physiological endpoints during and after the treatment.

And a recent study in a fish model suggests that T₂ can act as a ligand of the β-isoforms of the TH receptor. This could explain the effects of T₂ on pituitary and liver, whose TH-dependent physiologies occur by signaling through that receptor isoform. However, the cardiac hypertrophy observed by the authors at higher doses suggests that T₂ can also use the α1 receptor, the most abundant in this tissue.

Final Review of 3,5 Diiodotyrosine

After reading all the information about T2 or 3,5 Diiodotyrosine, I can conclude that T2 is a unique fat burner offering benefits quite an, unlike anything we’ve seen before. If you’re looking to lose fat fast, this is one to try! So I recommend you to buy products having T2 that is shown in this article.

References:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272398/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272398/

T2: The Lesser Known Thyroid Hormone

http://www.wilsonssyndrome.com/ThyroCare.htm

http://journal.frontiersin.org/article/10.3389/fphys.2014.00528/full