Ingredients: Phylloquinone

Ingredients: Phylloquinone

The History & Background of Phylloquinone

Type: Vitamins
Potency: 8/10

Phylloquinone is a circle of relatives of phylloquinones that contains a hoop of 2-methyl-1,four-naphthoquinone and an isoprenoid facet chain. Members of this group of diet K 1 have handiest one double bond at the proximal isoprene unit. Rich sources of diet K 1 consist of green flowers, algae, and photosynthetic bacteria. Vitamin K1 has antihemorrhagic and prothrombogenic pastime.

Phytomenadione became first remoted in 1939. It is on the World Health Organization’s List of Essential Medicines, the only and secure medicines needed in a health system. The wholesale value within the growing global is ready 0.11 to at least 1.27 USD for a 10 mg vial. In the United States a direction of remedy charges less than 25 USD. In 1943 Edward Doisy and Henrik Dam were given a Nobel Prize for its discovery.

Use in Supplements

Phylloquinone is regularly called nutrition K1. It is a fat-soluble vitamin this is strong to air and moisture but decomposes in daylight. It is found obviously in a huge sort of green plant life. Phylloquinone is also an antidote for coumatetralyl. Vitamin K is needed for the posttranslational change of sure proteins, commonly required for blood coagulation. Vitamin K facilitates your blood to clot (coagulate), preserve wholesome bones and help maintain blood vessels functioning properly.

Vitamin K is wanted for correct use of calcium in bones. Higher Vitamin K intake has been related to extra bone density, at the same time as low Vitamin K consumption has been located in elderly individuals with osteoporosis. There is growing proof that Vitamin K improves bone fitness and reduces hazard of bone fractures, especially in postmenopausal ladies who are at danger for osteoporosis.

The European Food Safety Authority (EFSA) confirms that clean fitness benefits were established for the nutritional consumption of Vitamin K in contributing to maintenance of stronger bones and normal blood circulation.

Common Dosing

To forego the issues of deficiency it’s far critical to get at least the RDA for nutrition K that is 1mcg in line with kg of body weight. It also assumed that 1/2 of this quantity comes from intestinal micro organism so that you can also have to regulate meals consumption in case you are on antibiotics. An easier manner to consider it’s miles 80mcg for men and 65 for girls.

However, if you are an active training athlete the RDA is greater than probable no longer enough for you and this is why athletes ought to comply with the PDI or Performance Daily Intake. The PDI for men and women is 80 to 180 mcg. The estimated secure variety for adults consuming nutrition K is 80 to 600 mcg in line with day.

Top Products Containing Phylloquinone

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Potential Side Effects of Phylloquinone

Common side effects when given by using injection include ache at the web site of injection and changed taste. Severe allergic reactions may also arise with injected right into a vein or muscle. It is uncertain if use for the duration of pregnancy is safe; but, use is in all likelihood in the course of breastfeeding. It works through providing a required factor for making some of blood clotting elements. Found assets include inexperienced veggies, vegetable oil, and some fruit.


What Is It? And Where Does It Come From?

Suspected to play a role as a vital nutrient since 1929 and finally isolated in 1939, Vitamin K is a group of three different fat soluble vitamins. Vitamin K1 (phylloquinone) is a natural form created and derived from green plants. The second form (menaquinone, vitamin K2) is another natural form made by animals and intestinal bacteria. Vitamin K3, the third form, is a synthetic that goes by the names menaphthone or menadione. Vitamin K3 is manufactured in a fat-soluble form that is roughly twice as potent as phylloquinone as well as a water-soluble form.

What Does It Do? And What Scientific Studies Give Evidence To Support This?

Back in 1929 when researchers first discovering vitamin K, it was found that chickens eating a diet containing only the essential nutrients (consequently devoid of vitamin K) developed hemorrhagic disorders. Ten years later when the vitamin was isolated, then established its role in proper blood clotting. Vitamin K plays this role by functioning in the creation of prothrombin and other proteins vital to blood clotting. Vitamin K is also involved in the creation of thrombin (a protein of importance in blood clotting) from prothrombin.

Vitamin K is also important in bones as it is necessary for the conversion of osteocalcin to its active form. This regulates the function of calcium in bone turnover as well as mineralization. Vitamin K aids in keeping bones, teeth and cartilage healthy as it is necessary for the function of a protein called MGP that is present in all three. Proper kidney function requires vitamin K to produce a urinary protein which inhibits the formation of calcium oxalate kidney stones.

Who Needs It? And What Are Some Symptoms Of Deficiency?

Deficiency is actually quite uncommon for anyone taking in a fairly balanced diet. However, it can develop in persons not eating green vegetables or those taking medicine that may interfere with the growth of intestinal bacteria which produce vitamin K2. Deficiency is also a risk in those suffering from prolonged diarrhea, obstructive jaundice, liver disease or malabsorption problems. Deficiency symptoms include a prolonged time till blood clotting, easy bleeding and bruising, blood stained urine and bleeding from the gut. Newborns and elderly are especially susceptible to deficiency.


In early radioisotopic research, healthy adults excreted about 60% to 70% of a unmarried oral dose of vitamin K within 3 days. The manufacturing of catabolites happens completely within the liver and the amount excreted via the biliary direction is approximately double that excreted inside the urine. Importantly, the identical 60% to 70% losses to the body were located regardless of whether the administered dose changed into within the dietary range (45 µg) or in the low pharmacological range (1 mg). This large excretion of phylloquinone explains the speedy turnover and depletion of hepatic phylloquinone located in patients located on a low nutrition K weight-reduction plan. The unchanged hepatic reserves of long-chain MK determined in the identical study is steady with their slower turnover as become also determined from plasma kinetics.

In an preliminary take a look at of three independent Caucasian cohorts, the CYP4F2 433M/M genotype became related to approximately 1 mg/day higher warfarin dose requirements compared to the V/V genotype, with heterozygotes requiring intermediate doses. Subsequent studies in Caucasians and Asians showed the affiliation between V433M genotype and warfarin dose requirements. The CYP4F2 V433M genotype explains about 1 to a few% of the general variability in warfarin dose in those populations.

Interestingly, the affiliation among CYP4F2 genotype and warfarin dose requirements was now not observed in African Americans, Indonesians, Egyptians, or youngsters. The lack of association in African Americans is probably because of the low frequency of the 433M allele in individuals of African ancestry. Body size gives a extra contribution to warfarin dose variability in kids versus adults, probably explaining the bad findings with the CYP4F2 genotype in a pediatric populace. However, the 433M allele is not unusual in Indonesians and Egyptians, and the cause of the terrible affiliation in these organizations is uncertain.

Final Review of Phylloquinone

In conclusion, Phylloquinone plays a major role in blood clotting, bone metabolism, and regulating blood calcium levels. Our body needs Phylloquinone to produce prothrombin, a protein and clotting factor that is important in blood clotting and bone metabolism. This benefits make Phylloquinone a great supplementation for everyone especially in bodybuilding. So you can have yours and refer to the product cited in this article.


Sources: 2020


This section can either be an intro or simple overview of the product. It might start with a benefit a person might want or offer them a solution.

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Harmony by 1st Phorm is a supplement designed for women to help keep hormones in check – specifically, the ones that wreak all types of havoc during PMS.

Released recently in 2019, Harmony has since then has gotten a lot of attention from women who want to look good all year round…no matter what.

But does 1st Phorm’s new product put your harmones back in “harmony” and reduce or eliminate the adverse symptoms of PMS?

In this review, we’ll look at the ingredients that are supposed to do the trick, consider all the facts, and look at the other experiences women have had while taking Harmony.


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Yerba Mate – Antioxidant that’s thought to be stronger than green tea. (Journal of Agricultural and Food Chemistry)

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Green Tea – Natural growth packed with EGCG, antioxidants, and a plethora of health benefits. According to WebMD, “It’s the healthiest thing I can think of to drink,” says Christopher Ochner, PhD. He’s a research scientist in nutrition at the Icahn School of Medicine at Mount Sinai Hospital.”

Kola Seed – Research shows kola nut may help with boosting energy and metabolism, improve circulation and digestion, and work as an antibacterial. (Journal of Biosciences and Medicines)

Schizonepeta – “Schizonepeta Tenuifolia is a herb that is commonly called Japanese Catnip of Jing Jie and is a traditional asian remedy (Chinese, Korean, and Japanese) for the common cold, headcolds, and allergic skin eruptions,” shares


In this section, we are going to cover every possible thing regarding side effects.

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People want to know…can I take this product?

In this section, it’s also fair to include things like special warnings for certain people, disclaimers, or anything else like that. When doing your research on the ingredients, you can simply take note of the side effects you notice for each one.

Instead of focusing on the specific product formula, we look closely at the specific product ingredients – and amounts of each ingredient – to determine possible side effects. The most common or important will be listed here. You can mention what to keep in mind, how to deal with and manage the side effects you experience, or what may causing them.

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Common side effects and what causes them

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Quotes from yourself: literally just quote yourself. Once you find out about a side effect, just add your opinion in the form of a quote (“I personally can deal with a small side effect like this to gain such huge benefits,” says one of our lead reviewers.)


Like other supplements, Harmony can have adverse side effects if not taken correctly. This product is not for use by women under 18 years of age. Avoid this if you are pregnant or breastfeeding.

Calcium D-glucarate, Maca (root), and KSM 66® Ashwagandha Root Extract make up the bulk of Harmony, so we’ll be focusing on these ingredients.

CDG can interact with alcohol and some medications that act on the liver. Alcohol might decrease the effectiveness of calcium D-glucarate. Taking calcium-D glucarate along with medications changed by the liver, such as acetaminophen (e.g., Tylenol), might also reduce the effectiveness of these medications.


Here we want to add the product benefits. It could be in the form of a paragraph, or bulleted. If we are recommending the product, here is our chance to sell it and tell them why they should use this product, or what is being claimed.


PMS is no joke, and supplements like Harmony are being manufactured daily to help fight effects like sluggishness, emotional mood swings, and the out of control food cravings that can occur.

Harmony also promises to reduce the symptoms of hormonal imbalance such as fatigue, acne, weight gain, infertility, low sex drive, etc.

If you are always tired, sleep-deprived, and anxious, or if you have insatiable food cravings, acne breakouts, or even low sex drive, this supplement can help keep you sane when you need it most.

Also, aside from helping eliminate the adverse effects of PMS, a lot of women have reported seeing improvements in skin, sleep, and higher energy levels throughout the day.


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The key to a toned and healthy body my
@Shredz Fat Burner and outdoor cardio #DollyCastro #Shredz…
— dolly castro (@Missdollycastro) March 3, 2015


Additional Methods

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As mentioned earlier, we have read over 40 reviews, and the vast majority reflect those on Amazon.

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It’s mainly a matter of degree of tolerability that determines whether or not the reviews are good or bad.

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Use the AIRTABLE LINK to find what products we recommend depending on the category.


Based on what we’ve seen, Harmony is a product that contains all the right ingredients, and each one has been picked to combat the effects of PMS.

1st Phorm seems to put together top-notch products and has a proven track record of high-quality supplements, so I’m sure this product won’t be any different.

There are 100s of other supplements like Harmony on, such as Happy Health Hippy, each ranging from $20-$50, with this one being on the higher end at $49.99.

But you get what you pay for. And the team at Suppreviewers give Harmony a 4.5-star recommendation.

We don’t think you can go wrong using anything by 1st Phorm.